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one hundred ten Notwithstanding the uncertainty concerning the best method, OTPs might take techniques to recognize patients who can be in danger for cardiac arrhythmia. The Idea pro panel concurs with the suggestions of other skilled panels (which incorporated cardiologists) that OTPs establish a cardiac threat management strategy,111,112 on the e

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4). Doses ought to be reduced for stories of indicators of opioid intoxication or oversedation. Dosing should be individualized determined by careful affected person evaluation and generally shouldn't be improved every single day, because plasma methadone ranges don't achieve regular point out until finally about five methadone half-lives (Exhibit

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